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online can make all the difference. https://images.squarespace-cdn.com/content/v1/59e44d550abd0479b9b94893/17bfd602-f578-44ed-9030-af25607c8c45/51215255659_b7f2963ca6_o.jpg News - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/59e44d550abd0479b9b94893/1621494926521-W4HM0D9QOQE7RBZQBEOY/Image+from+iOS+%2817%29.jpg News - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/59e44d550abd0479b9b94893/1593045704626-RFHFCE22FE4VKIGULXJ9/Screen+Shot+2020-04-08+at+11.24.46+am.png News https://images.squarespace-cdn.com/content/v1/59e44d550abd0479b9b94893/1579661579460-U775603AD5MN6Y3TBDZY/Guest+Speaker.jpeg News Lunch with guest speaker Professor Dan Tracey (Dec 2019) https://images.squarespace-cdn.com/content/v1/59e44d550abd0479b9b94893/1579661387640-DPL70NZ05LG1CAZRJZYW/John.ashx.jpg News John leaves for 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(Oct 2019) https://images.squarespace-cdn.com/content/v1/59e44d550abd0479b9b94893/1571783164015-RGF3C3UF2TFO11UJRB3K/greg+and+Lisa+PhD.jpg News 2019 Lisa Graduated and became DR Lisa Oyston! https://images.squarespace-cdn.com/content/v1/59e44d550abd0479b9b94893/1552455017101-M6538B7JRWX7BJ6K4DO0/lorne+lab+picture.jpg News 2019 Lorne Genome Conference https://images.squarespace-cdn.com/content/v1/59e44d550abd0479b9b94893/1545000052723-LR6YDNRC68PC1YEIGR05/Mate+Biro.jpg News 2018 Guest speaker Dr. Maté Biro (Dec) https://images.squarespace-cdn.com/content/v1/59e44d550abd0479b9b94893/1539296336272-9Q97P4QBZ6JNU1AYPMGT/Boston2.JPG News 2018 17th World Congress on Pain- Boston https://images.squarespace-cdn.com/content/v1/59e44d550abd0479b9b94893/1518992776119-4EL7SL7ND61TVSP11FLW/LorneCorr.jpg News 2018 Lorne Genome Conference (Feb) https://images.squarespace-cdn.com/content/v1/59e44d550abd0479b9b94893/1518992712281-5IHTCQ12YJHOJ86HPPHZ/Lab+photoAbove3.jpg News Group Photo Following Guest speaker A/PROF Shane Grey (Dec 2017) https://images.squarespace-cdn.com/content/v1/59e44d550abd0479b9b94893/1513129784084-HPM6ZFRY04G8HX30VB7N/GregKevinDark.jpg News - Felicity, Greg and Inspector Wang, Garvan Christmas party 2011 https://images.squarespace-cdn.com/content/v1/59e44d550abd0479b9b94893/1513129873344-FRHPQE0UNN6O8J8R4HKL/photobooth.jpg News https://images.squarespace-cdn.com/content/v1/59e44d550abd0479b9b94893/1513129934001-WPJCIVE2Y05ILUGM2A2K/photobooth.jpg News https://images.squarespace-cdn.com/content/v1/59e44d550abd0479b9b94893/1513137776672-HKHC5AWMYWKG8TIJYD9G/photobooth.jpg News https://images.squarespace-cdn.com/content/v1/59e44d550abd0479b9b94893/1513129834088-WSLDZYQYRK5AATZH9Y13/Lab+Group+old.jpg News - Garvan Lab photo, 2013 https://images.squarespace-cdn.com/content/v1/59e44d550abd0479b9b94893/1513129853265-3L6TQLA46IBQ4SZP2JC3/Lab+photo+newer.jpg News - Garvan Lab photo, 2015 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For this we need a better basic understanding of what is driving chronic pain including back pain, accidental injury, sciatica, cancer pain, shingles, and arthritis. To this end, we use new genome editing (CRISPR) and genetic techniques to find genes and pathways that are necessary and sufficient to drive pain diseases, and we study these new factors using fruit flies, mice, and human pain neurons grown from stem cells. We also apply high throughput drug screening to these systems to accelerate the chances of helping the ~70% of chronic pain patients that are currently not helped by existing drugs. https://images.squarespace-cdn.com/content/v1/59e44d550abd0479b9b94893/1714531281875-XYW4WKIYW370QZJYKTBV/chemo.png Research - Chemotherapy Resistance Using CRISPR we have evaluated all human genes for a role in resistance to commonly used chemotherapies and have identified the new gene RDD1 (Required for Drug-induced Death 1) which controls resistance to at least 7 chemotherapy agents. Importantly, RDD1 expression is reduced in a wide range of cancers (breast, colorectal, lung, ovarian, gastric, liver, kidney, sarcoma), and RDD1 levels can predict chemotherapy responses and overall patient survival. We know that RDD1 plays a role in cancer cell death somehow, but since we only recently found this gene, we don’t know the mechanisms involved and are actively investigating this. This work can teach us more about how human cells live and die, will help us enhance the potency of existing chemotherapies or make new more targeted anti-cancer drugs. https://images.squarespace-cdn.com/content/v1/59e44d550abd0479b9b94893/1714531300778-9H2QN0K5QEFXI8VSZHYL/organoid.jpg Research - Human stem cell & organoid biology Mouse genetics made a major impact on our ability to treat human disease in the 20th century, however major advances in 21st century medicine will be driven by human genetics and stem cell biology. Over the last 10 years there has been a revolution in our ability to make and genetically change human stem cells. We can now generate most human organs (called organoids) in a dish, and can use CRISPR to change the genetic code and learn more about how our genes contribute to disease. Moreover, we can combine these technologies with high throughput drug screening to find new medicines that we know will work in the human system. We are applying these technologies to human brain development, the human pain system, muscular dystrophy or wasting, and more recently looking at how COVID-19 interacts with human lung organoids and potential drugs. https://images.squarespace-cdn.com/content/v1/59e44d550abd0479b9b94893/1714531312772-RCIGBM3P63EKYBDX6ULA/lifespan.jpg Research - Lifespan We have become interested in what controls an animal’s lifespan, and if its possible to extend lifespan while preserving cognitive function. Again, starting with human genomics information (association or DNA/RNA sequencing), we have targeted hundreds of conserved neuronal genes and pathways looking for lifespan extension effects in the fly. From this effort we have identified ~40 new genes that when targeted can extend lifespan, some of can also preserve cognitive function in aged animals. We continue to investigate these new genes, placing them in existing lifespan pathways or in some cases what appear to be completely novel organ-specific lifespan regulating pathways. https://www.neelylab.com/people-copy daily 0.75 2024-03-07 https://images.squarespace-cdn.com/content/v1/59e44d550abd0479b9b94893/1687998985832-LG0I34IENPEHAHFPFTIA/IMG_20220617_210457_576+%281%29.jpg People https://images.squarespace-cdn.com/content/v1/59e44d550abd0479b9b94893/1605241749135-MVIIEVD6F4T31W5NZ439/Image+from+iOS.jpg People https://images.squarespace-cdn.com/content/v1/59e44d550abd0479b9b94893/1709709371565-UFEJBWX417SOPSRY1AJF/Lipin.jpg People - Dr Lipin Loo (Copy) https://images.squarespace-cdn.com/content/v1/59e44d550abd0479b9b94893/1709709200348-VC065STG39JQPH95PR3M/Arjun.jpg People - Dr Arjun Muralidharan (Copy) https://images.squarespace-cdn.com/content/v1/59e44d550abd0479b9b94893/1709708971190-3Q3BW1A6P1C2XDOMMP72/Chris%2BD%2Bphoto.jpg People - Dr Christopher Denes (Copy) Research Fellow https://images.squarespace-cdn.com/content/v1/59e44d550abd0479b9b94893/1709709313005-F45E8CCOWZLD3S4XAY74/CesarWebsite.jpg People - Dr Cesar Moreno (Copy) xxxxx https://images.squarespace-cdn.com/content/v1/59e44d550abd0479b9b94893/1709709647521-8NGCY5DH6LH586DSPBRM/Maria%252BG%252Bphoto.jpg People - Dr Maria Bergamasco (Copy) XXXXX https://images.squarespace-cdn.com/content/v1/59e44d550abd0479b9b94893/1709764452301-1FFJSPG9M8OH5VCIGLIU/Kaz+photo.jpg People - Dr Kazuma Fujikake (Copy) https://images.squarespace-cdn.com/content/v1/59e44d550abd0479b9b94893/1709709472590-XZ6WB9LOGT9EZYPL6YW1/Willie.jpg People - Dr Willie Lin (Copy) https://images.squarespace-cdn.com/content/v1/59e44d550abd0479b9b94893/1709765366896-S09G3RBX4O8FZI97IKPI/Blank+photo.jpeg People - Teleri Clark (Copy) https://images.squarespace-cdn.com/content/v1/59e44d550abd0479b9b94893/1709762934166-ACSB93ERYPU7SE5EKQQH/Waller%2Bprofile.jpg People - Matthew Waller (Copy) https://images.squarespace-cdn.com/content/v1/59e44d550abd0479b9b94893/1709762979168-VLF5DFAV00KFDMZW4BD6/Tian.jpg People - Tian Du (Copy) https://images.squarespace-cdn.com/content/v1/59e44d550abd0479b9b94893/1709763027364-VX598B055NURXUGREP4E/James+photo.jpeg People - James Rawson (Copy) https://images.squarespace-cdn.com/content/v1/59e44d550abd0479b9b94893/1709763060924-30GKZRB2BUX04R9IARAZ/Miriam.jpg People - Miriam Puehl (Copy) https://images.squarespace-cdn.com/content/v1/59e44d550abd0479b9b94893/1709765433742-O0KZMIC3YMAXZA5LMAOB/Blank+photo.jpeg People - Jasmine Kaur (Copy) https://images.squarespace-cdn.com/content/v1/59e44d550abd0479b9b94893/1709710356667-76NUSIBZJNWF5M3066KC/Sophie+P+photo.jpg People - Sophie Preston (Copy) https://images.squarespace-cdn.com/content/v1/59e44d550abd0479b9b94893/1709770051749-4DSOLP32LDQENG8MJFOH/Emma%2Bphoto.jpg People - Emma Viol (Copy) https://images.squarespace-cdn.com/content/v1/59e44d550abd0479b9b94893/1709710428510-RTNFW2RGMW6Z5Q7LE685/Hannah+S+photo.jpg People - Hannah Scarborough (Copy) https://images.squarespace-cdn.com/content/v1/59e44d550abd0479b9b94893/1709710741947-CWTUGDP5CPSLLU64XNA6/Phoebe%2Bphoto.jpg People - Phoebe Yu (Copy)