Our lab is focused on the systematic functional annotation of the genome. The long-term objective of our research is to identify genes and coding mutations that participate in major age-related and neurological diseases. Our overall research strategy is to combine human population genomics (GWAS or sequencing) data with high throughput functional validation in fruit flies and mammalian systems to identify new genes that contribute to human disease.
We have developed novel functional genomics strategies that we use to identify genes involved in various normal or disease states. Currently we have projects that relate to heart function, pain perception, neurodegeneration, lifespan and metabolic disorders, kidney function, and cancer. In the end our goal is to rapidly improve patient treatment, and many of the new genes we have identified appear to be viable drug targets.
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